September 11, 2009

Science and Environment

Interview

Physics and Aging

Dan Cloer

In How and Why We Age, Leonard Hayflick, best known for his research in cell biology and mycoplasmology, argued more than a decade ago that aging is inevitable. Our biological clocks are ticking, the professor of anatomy at University of California–San Francisco wrote; but alas, “we have no way of measuring it.” Noting that “each of our many tissues and organs behaves like an independent clock ticking at a rate different from that of the others,” Hayflick argued that there is no way to outwit eventual molecular breakdown. “Today,” he continued, “there is a growing belief that efforts should be made to extend life as much as possible, provided that the quality of life is maintained. . . . But even a joyous life should not, in my view, last forever. The consequences of an ageless population would be bizarre, even terrifying.”

Vision contributor Dan Cloer asked Hayflick to comment further on the relationship between aging and longevity. 

 

DC In your article “Entropy Explains Aging,” you write, “Energy dispersal is never entirely eliminated but it can be circumvented for various time periods by repair and replacement processes,” and that “what changes with age is an animal’s ability to adapt to the constant forces of natural selection.” Would you elaborate on the relationship between these two statements? 

LH Energy dispersal ultimately results in loss of molecular structure, hence function. This is an ongoing process from conception. Repair, synthesis and turnover (i.e., maintenance processes or longevity determinants), keep the balance in favor of more repair than damage until after reproductive maturation, or the species will vanish. After that time, the balance slowly shifts so that maintenance cannot keep up with molecular damage. I am not equating natural selection with entropy; there is no selective pressure to maintain repair processes indefinitely. This is why animals and plants age and are mortal. 

DC If we consider the large primate expiration date to be about twice the maturation age, why do we live so long as it is? Wouldnt 30 years be old enough to have and raise a child to its maturation age? 

LH Only in the last 100 years have humans had a life expectancy of over 45 years at birth. For 99.999 percent of the time weve been human, life expectancy was about 18 to 25 years at birth. Few feral animals ever live long enough to experience serious age changes unless man has tampered with their ecological niche. This has happened in recent decades. 

DC Although lifestyles play a role in cancer and cardiovascular disease development, arent these diseases inevitable unless we determine how to extend the organisms self-repair mechanisms? 

LH Yes. 

DC Is the goal, then, for us to take up the reins and step in to become the new selective force to change our own genetic systems or create new interventions to maintain these mechanisms? 

LH No, the goal is to resolve age-associated diseases, not to extend human longevity. The latter is fraught with unintended consequences. The key question to ask is, why is an old cell more vulnerable to pathology than a young cell? Intracellular age changes (and some extracellular matrix changes) may be the ultimate cause of all age-associated diseases. The physician’s mantra is that “the greatest risk factor for age-associated diseases is aging.” So why are we not studying the fundamental biology of aging? 

My argument is that the present insignificant allotment of resources directed toward understanding the aging process is a $1 billion misunderstanding. Under the rubric of “aging research,” funds are spent mostly on the resolution of age-associated diseases that will tell us nothing about the fundamental biology of aging. In the same way, the resolution of many childhood diseases told us nothing about childhood development. 

DC Aubrey de Grey calls aging a disease. You write that “the fundamental aging process is not a disease, but it increases the vulnerability to disease.” Is this a case of both of you meaning the same thing but using vocabulary differently? 

LH Aubrey does not understand the difference between aging and disease. Aging is not a disease for at least six reasons. Unlike any disease, age changes  

  • occur in every animal that reaches a fixed size in adulthood; 
  • cross virtually every species barrier; 
  • occur in all species members only after the age of reproductive maturation; 
  • occur in feral animals protected by humans even after that species probably has not experienced aging for thousands or millions of years [since in the wild they would typically die long before being debilitated by age];  
  • increase the vulnerability to pathology and death in all animals in which it occurs; 
  • have the same universal molecular etiology—that is, thermodynamic instability—in both animate and inanimate objects.